Correlation between functional and ultrastructural substrate in Brugada syndrome
نویسندگان
چکیده
Pablo E. Tauber, MD, Virginia Mansilla, MD, Guillermo Mercau, MD, Felix Albano, MD, Ricardo R. Corbalán, Sara S. Sánchez, PhD, Stella M. Honoré, PhD From the Electrophysiology Division, Model Heart Center, San Miguel de Tucumán, Argentina, Unit of Arrhythmias and Electrophysiology, ZJS Hospital Health Center, San Miguel de Tucumán, Argentina and Departamento Biología del Desarrollo, INSIBIO (Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional de Tucumán) (CONICET-UNT) San Miguel de Tucumán, Argentina.
منابع مشابه
Local activation delay exacerbates local J-ST elevation in the epicardium: Electrophysiological substrate in Brugada syndrome
Introduction The mechanisms of J-ST elevation in the right precordial leads in patients with Brugada syndrome (BrS) remain controversial (ie, repolarization vs depolarization hypotheses). Recently, epicardial substrate ablation for late fractionated potentials and a low-voltage area (LVA) in the right ventricular outflow tract (RVOT) has been performed for ventricular fibrillation (VF) that is ...
متن کاملA case of Brugada Syndrome unmasked by a postoperative febrile state
Abstract Background: Brugada Syndrome (BS) is an inherited ion channelopathy characterized by an electrocardiographic (ECG) pattern of a coved type ST segment elevation in right precordial leads with or without right bundle branch block. Case Presentation: A 23-year old male presented with right lower quadrant abdominal pain. Further evaluation revealed a diagnosis of acute appendicitis. The ...
متن کاملNa(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.
BACKGROUND Complex physiological interactions determine the functional consequences of gene abnormalities and make mechanistic interpretation of phenotypes extremely difficult. A recent example is a single mutation in the C terminus of the cardiac Na(+) channel, 1795insD. The mutation causes two distinct clinical syndromes, long QT (LQT) and Brugada, leading to life-threatening cardiac arrhythm...
متن کاملMechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.
BACKGROUND Although phase 2 reentry is said to be responsible for initiation of ventricular tachycardia (VT) in Brugada syndrome, information about the activation sequence during VT is limited. METHODS AND RESULTS We developed an experimental Brugada syndrome model using a canine isolated right ventricular preparation cross-circulated with arterial blood of a supporter dog and examined the VT...
متن کاملEpicardial Brugada syndrome ablation unmasking inferior J waves.
Patients with Brugada syndrome are at risk of life-threatening ventricular arrhythmias. Epicardial substrate ablation for Brugada syndrome has been described as a means of controlling these arrhythmias and recent reports describe elimination of the Brugada phenotype with ablation. We describe a unique case in which a patient developed inferior J waves with an early repolarization-type electroca...
متن کامل